About Us >> Faculty >>Moniri

Nader Moniri, Ph.D.

Assistant Professor, Department of Pharmaceutical Sciences

Contact Information
3001 Mercer University Drive, DV-122
Atlanta, GA 30341
(678) 547-6246
Fax: (678) 547-6364
moniri_nh@mercer.edu

Faculty Website: http://faculty.mercer.edu/moniri_nh/index.html

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Educational Background

B.S., Biological Sciences, Georgia State University
Ph.D., Pharmaceutical Sciences, University of North Carolina-Chapel Hill
Post-doctoral Fellow, Pharmacology, Duke University Medical Center

Research Background and Interests

Dr. Moniri's training has focused on molecular pharmacology and signal transduction of G protein-coupled receptors (GPCR) as well as the design and development of novel agents which modulate GPCR function.

Current research interests include signal transduction, alternative signaling, and design of functionally selective modulators of the prototypical GPCR, the b2-adrenergic receptor. Specifically, this work seeks to characterize mechanisms of b2-receptor mediated generation of intracellular reactive oxygen species, formation of which we have recently shown to be indispensable for receptor function.

Dr. Moniri's laboratory is also interested in characterization of neuro-endocrine GPCRs which are involved in glucagon/insulin homeostasis, food intake, and satiety, as well as development of novel anti-diabetic agents which target these GPCRs.

For a more detailed description of research in Dr. Moniri's laboratory click here.

Selected Publications

Moniri NH and Daaka Y.  Agonist-stimulated reactive oxygen species formation regulates beta-2-adrenergic receptor signal transduction.  Biochemical Pharmacology, 74: 64-73, 2007.  

Booth, RG and Moniri, NH.  Novel ligands stabilize stereo-selective conformations of the histamine H1 receptor to activate catecholamine synthesis. Inflammation Research, 56:S1-2, 2007.

Moniri, NH and Booth, RG. Role of PKA and PKC in Histamine H1 Receptor-Mediated Activation of Catecholamine Neurotransmitter Synthesis. Neuroscience Letters, 407:249-253, 2006.

Bagchi, G; Moniri, NH; Daaka Y. Androgen Receptor. Nature AFCS-Molecules Pages, 2006.

Guo, R; Kasbohm, EA; Arora, P; Sample, CJ; Baban, B; Sud, N; Sivashanmugam, P; Moniri, NH; Daaka, Y. Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells. Endocrinology, 147:4883-4892, 2006.

Wang, G; Moniri, NH; Ozawa, K; Stamler, JS; Daaka, Y. Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. Proceedings of the National Academy of Sciences, USA, 103(5):1295-1300, 2006.

Courses
PHA 450 Nervous System I
PHA 453 Cardiovascular/Renal Disorders II
PHA 550 Musculoskeletal Disorders
PHA 554 Infectious Diseases I
PHA 899 Doctoral Research

Click here for more information on Dr. Moniri.